By Eleazar Shafrir, Anders A F Sima
Animal versions of Diabetes: A Primer introduces features of the main generic animal species with numerous diabetic syndromes that have been built and largely investigated over the last few a long time. It contains animal types which are available, good defined and confirmed to be of price within the learn of either kinds of diabetes. largely referenced, this booklet could be of worth to new and validated investigators, graduate scholars and pharmaceutical scientists engaged on the improvement of antidiabetic and preventative modalities in quite a few components of diabetes and its problems.
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Additional info for Animal Models in Diabetes: A Primer (Frontiers in Animal Diabetes Research)
Phenotype The phenotype of the autoreactive cell population has been partially characterized. , 1993). Additional data suggest that this population may in part be comprised of long-lived CD8low T cells (Bellgrau and Lagarde, 1990). , 1991). , 1994). These observations raise the possibility that different cell types are involved in the initiation of autoreactivity vs. the actual implementation and amplification of beta cell killing by recruited cytotoxic cell populations. Finally, it has been observed that CD4+ CD45RChigh (clone OX22hlgh) T cells are capable of initiating a wasting graft vs.
Atkinson, M. H. (1999) The NOD mouse model of insulin dependent diabetes: as good as it gets? , In press. L. A. (1995) Genetics of the BB rat: Association of autoimmune disorders (diabetes, insulitis and thyroiditis) with lymphopenia and major histocompatibility complex class II. Endocrinology, 136, 5731–5735. , et al. (1998) Rat NKR-P1+ CD3+ T cells: selective proliferation in interleukin-2, diverse T-cell-receptor-Vb repertoire and polarized interferongamma expression. Immunology, 95, 117– 125.
419, 253–256. , Nieuwenhuis, P. and Kampinga, J. (1989) Peripheral T cells in diabetes prone (DP) BB rats are CD45R-negative. Thymus, 14, 145–150. L. (1994) Diabetes-prone and diabetes-resistant BB rats: Animal models of spontaneous and virally induced diabetes mellitus, lymphocytic thyroiditis and collagen-induced arthritis. ILAR News, 35, 29–37. , Kastern, W. A. (1989) Genetic studies in inbred BB/ Wor rats: Analysis of progeny produced by crossing lymphopenic diabetes-prone rats with nonlymphopenic diabetic rats.
Animal Models in Diabetes: A Primer (Frontiers in Animal Diabetes Research) by Eleazar Shafrir, Anders A F Sima