By Martin Holcik, Eric C. LaCasse, Alex E. MacKenzie, Robert G. Korneluk
The method of programmed phone loss of life or apoptosis has, within the decade previous the ebook of this 2005 publication, been proven to be centrally eager about the pathogenesis of the numerous majority of human health problems and damage states. The mobile attrition saw in so much degenerative stipulations is apoptotic in nature; conversely a failure of apoptosis has been proposed to underlie many varieties of melanoma. The imperative function of apoptosis in human affliction essentially brings with it medical promise; for instance, the powerful danger exists that attenuation of apoptotic dying will considerably modulate the severity of degenerative issues. equally, stipulations, comparable to melanoma, autoimmune illness, psoriasis and endometriosis, during which aberrant mobile proliferation is saw, may gain advantage from greater charges of apoptosis. This e-book surveys the underlying molecular mechanisms of apoptosis, investigates its function in degenerative and different ailments, and evaluates power cures that would allow applicable activation or inhibition of apoptosis in ailment and harm states.
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Extra resources for Apoptosis in Health and Disease: Clinical and Therapeutic Aspects
J. (1999). The correlativity analysis of six methods of detecting apoptosis. Chin. Med. Sci. , 14, 145–51. Linton, S. , Karanewsky, D. , Ternansky, R. J. et al. (2002). Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization. Bioorg. Med. Chem. , 12, 2969–71. , Fong, W. , Kelly, N. L. et al. (2001). Identification of XAF1 as an antagonist of XIAP anti-caspase activity. Nat. , 3, 128–33. , Tamai, K. et al. (1996). Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.
USA, 95, 195–200. , Ona, V. , Li, M. et al. (2000). Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat. , 6, 797–801. , Spencer, D. , and Wang, J. (2002). Activation of initiator caspases through a stable dimeric intermediate. J. Biol. , 277, 50761–7. Chene, P. (2003). Inhibiting the p53-MDM2 interaction: an important target for cancer therapy. Nat. Rev. Cancer, 3, 102–9. , Griffin, J. H. et al. (2003). Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective.
2003). In vivo monitoring of apoptosis. Prog. Neuropsychopharmacol. Biol. Psychiatry, 27, 323–31. Brekke, O. H. and Sandlie, I. (2003). Therapeutic antibodies for human diseases at the dawn of the twenty-first century. Nat. Rev. , 2, 52–62. Brummelkamp, T. , Nijman, S. , Dirac, A. , and Bernards, R. (2003). Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. Nature, 424, 797–801. Bullock, A. N. and Fersht, A. R. (2001). Rescuing the function of mutant p53.
Apoptosis in Health and Disease: Clinical and Therapeutic Aspects by Martin Holcik, Eric C. LaCasse, Alex E. MacKenzie, Robert G. Korneluk